| Date | Home | Away | Result |
|---|---|---|---|
| 09/01/25 19:00 | Sheffield United | Cardiff City | 0-1 |
| 09/01/25 19:45 | Fulham FC | Watford FC | 4-1 |
| 09/01/25 19:45 | Everton FC | Peterborough United | 2-0 |
| 10/01/25 19:45 | Wycombe Wanderers | FC Portsmouth | 2-0 |
| 10/01/25 20:00 | Aston Villa | West Ham United | 2-1 |
| 11/01/25 12:00 | Middlesbrough FC | Blackburn Rovers | 0-1 |
| 11/01/25 12:00 | Bristol City | Wolverhampton Wanderers | 1-2 |
| 11/01/25 12:00 | Birmingham City | Lincoln City | 2-1 |
| 11/01/25 12:15 | Liverpool FC | Accrington Stanley | 4-0 |
| 11/01/25 14:00 | Leicester City | Queens Park Rangers | 6-2 |
| 11/01/25 15:00 | Nottingham Forest | Luton Town | 2-0 |
| 11/01/25 15:00 | Norwich City | Brighton and Hove Albion | 0-4 |
| 11/01/25 15:00 | Reading FC | Burnley FC | 1-3a.e.t |
| 11/01/25 15:00 | Exeter City | Oxford United | 3-1 |
| 11/01/25 15:00 | AFC Bournemouth | West Bromwich Albion | 5-1 |
| 11/01/25 15:00 | Chelsea FC | FC Morecambe | 5-0 |
| 11/01/25 15:00 | Brentford FC | Plymouth Argyle | 0-1 |
| 11/01/25 15:00 | AFC Sunderland | Stoke City | 1-2a.e.t |
| 11/01/25 17:45 | Leeds United | Harrogate Town FC | 1-0 |
| 11/01/25 17:45 | Manchester City | Salford City | 8-0 |
| 11/01/25 18:00 | Coventry City | Sheffield Wednesday | 5-4a.PSO |
| 12/01/25 12:00 | Hull City A.F.C. | Doncaster Rovers | 5-6a.PSO |
| 12/01/25 12:30 | FC Tamworth | Tottenham Hotspur | 0-3a.e.t |
| 12/01/25 15:00 | Crystal Palace | Stockport County | 1-0 |
| 12/01/25 15:00 | Ipswich Town | Bristol Rovers | 3-0 |
| 12/01/25 15:00 | Arsenal FC | Manchester United | 4-6a.PSO |
| 12/01/25 15:00 | Newcastle United | Bromley FC | 3-1 |
| 12/01/25 16:30 | Southampton FC | Swansea City | 3-0 |
| 13/01/25 19:30 | Millwall FC | Dagenham and Redbridge | 3-0 |
| 14/01/25 19:45 | Leyton Orient | Derby County | 7-6a.PSO |
| 14/01/25 19:45 | Mansfield Town | Wigan Athletic | 0-2 |
| 14/01/25 19:45 | Preston North End | Charlton Athletic | 2-1 |